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KMID : 0816119990020010040
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Korean Journal of Pediatric Gastroenterolology and Nutrition
1999 Volume.2 No. 1 p.40 ~ p.45
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Seroepidemiology of Hepatitis A and Hepatitis B in Korean Children
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Ko Jae-Sung
Bae Sun-Hwan
Chung June-Key
Seo Jeong-Kee
Chung Ju-Young
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Abstract
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Purpose: The aim of this study is to investigate the seroepidemiology of hepatitis A
and hepatitis B in Korean children.
Methods: 801 children aged 6 to 12 years were enrolled. IgG antibody to hepatitis A
virus (anti-HAV), hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs),
and IgG antibody to HBc (anti-HBc) were measured by radioimmunoassay.
Results: Of the 801 children, the seroprevalence of anti-HAV was 0%. Three (0.4%)
were seropositive for HBsAg. The seroprevalence of anti-HBs was 61.8%. Two (0.4%)
of 495 anti-HBs positive subjects were positive for anti-HBc. Of the 801 children, 658
(82.1%) had received hepatitis B vaccination.
Conclusions: Since natural anti-HAV is not acquired in the childhood, the outbreak of
hepatitis A is possible in adolescents and young adults. The decrease in seroprevalence
of HBsAg and the increase in seroprevalence of anti-HBs might result from hepatitis B
vaccination program in childhood.
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KEYWORD
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Hepatitis A, Hepatitis B, Seroepidemiology, Children,
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